Effect of acetylcholine on the secretion of gut glucagon immunoreactivity and gut glucagon-like immunoreactivity in pancreatectomized dogs.
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چکیده
منابع مشابه
The effects of triglyceride absorption upon glucagon, insulin, and gut glucagon-like immunoreactivity.
The effects of a fat meal upon plasma insulin, glucagon, and glucagon-like immunoreactivity (GLI) have been studied in conscious dogs and in human volunteers. In dogs the intraduodenal instillation of 10 g/kg of peanut oil was accompanied by increases in the mean plasma levels of all three polypeptides that averaged 5 muU/ml, 107 pg/ml, and 2.1 ng/ml, respectively. 3 g/kg of peanut oil, when em...
متن کاملEvidence for transformation of glucagon-like immunoreactivity of gut into pancreatic glucagon in vivo.
The effect of gut glucagon-like immunoreactivity (GLI) devoid of pancreatic glucagon was studied in piglets. All glucagon-like peptides with an accessible C-terminal were removed from the gut extract by specific antibodies reacting with the C-terminal of the glucagon molecule. Endogenous secretion of pancreatic and gut glucagon was blocked by somatostatin infusion, and then the purified gut glu...
متن کاملIncreased plasma glucagon-like immunoreactivity in dogs with ileojejunal transposition.
To elucidate hormonal and metabolic changes in intestinal adaptation, an experimental study was performed in dogs subjected to ileojejunal transposition. Fasting levels of blood glucose, plasma insulin and gastric inhibitory polypeptide (GIP) did not change significantly throughout 12 weeks. Plasma glucagon measured with an antiserum specific to the C-terminal portion of glucagon slightly incre...
متن کاملThe effect of calcium and other salts upon the release of glucagon-like immunoreactivity from the gut.
It has been suggested that glucagon-like immunoreactivity (GLI) of gastrointestinal tissues might, like pancreatic glucagon, have calcium-lowering activity. Studies were designed, therefore, to determine if calcium absorption was associated with GLI release from the gut. The intraduodenal administration of 4.5 mmoles of calcium chloride per kg of body weight to conscious dogs was associated wit...
متن کاملGut adaptation and the glucagon-like peptides.
The glucagon-like peptides GLP-1 and GLP-2 are synthesised and then released from enteroendocrine cells in the small and large intestine. GLP-1 promotes efficient nutrient assimilation while GLP-2 regulates energy absorption via effects on nutrient intake, gastric acid secretion and gastric emptying, nutrient absorption, and mucosal permeability. Preliminary human studies indicate that GLP-2 ma...
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ژورنال
عنوان ژورنال: Endocrinologia Japonica
سال: 1980
ISSN: 0013-7219,2185-6370
DOI: 10.1507/endocrj1954.27.33